Im on metformin 500 mg,24 hr. Tabs once a day,I take it with my supper.an the dr. Has me checking on meter,my fasting an before supper. And im so far just watching my diet. My ac1 was 6.3,an fasting 120,when the dr. Took good work. But my family history is sooo very bad,that I wasn't surprised. So im glad she caught it in time,I've also lost 10 lbs. Need to lose at least 10 more. Thank you