Thanks for the reply. I took it for the anti inflammatory benefits, but I had read that there were positive effects on glucose control, too. If I can find the article again, I will add the link. I have just started back on quercetin, so I will be interested in you input on this supplement.I have been the last month or so. I got it because I read it was supposed to help with supressing covid virus replication. Never gave a thought to an interaction with metformin, but looking just now looks like one effect is it works to fight prostrate cancer. Both individually are supposed to have anti-inflammatory properties and protection from some cancer cells. I guess I need to do some more looking, I may want to keep it as a daily supplement. Thanks for bringing this up.