I have been doing research on Actos and some of the side effects that it has. I am not sure that I trust this drug anymore. There is some controversy about whether this drug causes heart problems. My bout with pneumonia has me questioning the affect that it may be causing. I am currently using 2 liters of oxygen on a continuous basis. Tonight I needed to get out of the house and decided to take the trash out to the curb for pick-up. I wasn't going to bother hooking up the oxygen tank just to go to the curb. By the time I walked 35 feet, I was feeling very short of breath. I would have not been released from the hospital last Friday, without oxygen therapy in place at home. My 02 levels are 78% on room air and 98% on 2 liters of oxygen. I simply must see if stopping Actos might help with the shortness of breath. This is not the quality of life that I want. I really wish that I understood more about the heart and lungs. I have been told that I do not have any heart problems and have had a recent cardiac stress test that was very normal and my cardiac enzymes are normal, EKG's are normal. I still feel a part of the puzzle is missing.