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Hi Flower: :)

Welcome. The generic/substitute to Amaryl is Glimepiride. If that is what you are referring to. Amaryl(Glimepiride) is to be used along with diet and exercise to aid in controlling blood sugars.

Weight-gain is not a side-effect of Amaryl(Glimepiride). If you experience unusual or sudden weight-gain while using these drugs, then you should call your Dr. immediately, for further advice.
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