In some people it can . . . in others not. I still drink one large mug (16 oz) of caffeinated most days, and I drink it with heavy cream. The only time I thought coffee was spiking me was when I was "spiking" IT with non-dairy-creamer, which in turn was spiking ME with all its corn syrup solids & other carby ingredients! So no more creamer in this house . . .Interesting. Coffee can produce glucose spikes? I have not heard that nor experienced it. I drink at least 5 cups per day (no sugar though)...my main drink. Juice for breakfast and milk for lunch and dinner but coffee is my main staple (vice).